Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes.
Michael V SchrodtRiley M Behan-BushJesse N LiszewskiMadeleine E Humpal-PashLauren K BolandSabrina M ScrogginsDonna A SantillanJames A AnkrumPublished in: Stem cell research & therapy (2023)
Collectively, these studies show that the quality of MSCs efferocytosed by monocytes polarize monocytes toward distinctive immunosuppressive phenotypes and highlights the need to tailor MSC therapies for specific indications.