Login / Signup

Tumour-infiltrating lymphocyte subsets and their individual prognostic impact in oral squamous cell carcinoma.

Aanchal KakkarRishikesh ThakurDiya RoyRidhi SoodAtul SharmaRajeev Kumar MalhotraAlok Thakar
Published in: Journal of clinical pathology (2023)
Host immune response and its interaction with cancer cells have a significant impact on OSCC outcomes, with some TIL subsets being more clinically relevant than others. High cytotoxic T-cell (CD8) and low Treg (FOXP3) counts, and high cytotoxic T-cell to Treg (CD8:FOXP3) ratio are significantly associated with favourable prognosis. These results may serve as a leading point in identifying novel therapeutic agents that can redesign the tumour immune microenvironment by reducing infiltrating FOXP3-lymphocytes, and modifying their signalling pathways.
Keyphrases
  • peripheral blood
  • regulatory t cells
  • immune response
  • dendritic cells
  • stem cells
  • nk cells
  • type diabetes
  • toll like receptor
  • weight loss