Genetic Polymorphisms Affecting the Pharmacokinetics of Antiretroviral Drugs.

Andrea CalcagnoJessica CusatoAntonio D'AvolioStefano Bonora

Published in: Clinical pharmacokinetics (2017)

Genetic polymorphisms may affect antiretroviral disposition, as well as both efficacy and toxicity. Despite a large amount of data, such precious knowledge has seldom been applied in patients. Studies on the clinical relevance and cost effectiveness of tailoring antiretroviral regimens to patients' genetic assets are lacking, but their importance may grow with the increasing age and complexity of persons living with HIV/AIDS.

Keyphrases

hiv aids
end stage renal disease
hiv infected
ejection fraction
newly diagnosed
chronic kidney disease
antiretroviral therapy
peritoneal dialysis
healthcare
prognostic factors
oxidative stress
hiv infected patients
gene expression
dna methylation
patient reported outcomes
data analysis
copy number