Assessing the Benefits and Risks of Amantadine for Irritability and Aggression after Traumatic Brain Injury.

Flora M HammondRoss D ZafonteMark ShererKathleen R BellJennifer BognerJames F MalecQing TangJeong Hoon Jang

Published in: PM & R : the journal of injury, function, and rehabilitation (2023)

Clinician ratings suggest modest benefit of amantadine 100mg twice daily with low risk to appropriately selected patients with adequate renal clearance. Thus, amantadine should be considered a treatment option for the experienced brain injury clinician. These data may support treatment decisions when a pharmaceutical agent is being considered to control irritability/aggression. This article is protected by copyright. All rights reserved.

Keyphrases

brain injury
subarachnoid hemorrhage
physical activity
combination therapy
machine learning
big data
deep learning
artificial intelligence
replacement therapy