Data-independent acquisition for proteomic applications in early-stage endometrial cancer progression.

Yuemei Cheng Yijuan Xing Junhong Du Dan Hu Xiaolei Liang Chang Liu Yongxiu Yang

Published in: The journal of obstetrics and gynaecology research (2023)

Our present works elucidate that metabolism reprogramming is associated with high-grade, early-stage EC, particularly OXPHOS is upregulated. Noticeably, the paracancerous tissues have undergone molecular changes similar to cancer tissues, maybe they have signal exchange via secreted proteins (ITGA4 and COL4A1). The upregulation of OXPHOS-related proteins may be the potential biomarker for EC diagnosis, and targeting OXPHOS metabolism might be an effective treatment for high-grade, early-stage EC.

Keyphrases

early stage
high grade
endometrial cancer
low grade
sentinel lymph node
gene expression
papillary thyroid
electronic health record
squamous cell
signaling pathway
big data
machine learning
drug delivery
long non coding rna
lymph node metastasis
artificial intelligence
locally advanced