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Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development.

Lúcio Ricardo Leite DinizMarilia Trindade de Santana SouzaJoice Nascimento BarbozaReinaldo Nóbrega de AlmeidaDamião Pergentino de Sousa
Published in: Molecules (Basel, Switzerland) (2019)
Depression is a health problem that compromises the quality of life of the world's population. It has different levels of severity and a symptomatic profile that affects social life and performance in work activities, as well as a high number of deaths in certain age groups. In the search for new therapeutic options for the treatment of this behavioral disorder, the present review describes studies on antidepressant activity of cinnamic acids, which are natural products found in medicinal plants and foods. The description of the animal models used and the mechanisms of action of these compounds are discussed.
Keyphrases
  • major depressive disorder
  • healthcare
  • mental health
  • public health
  • depressive symptoms
  • human health
  • combination therapy
  • physical activity
  • climate change
  • replacement therapy