Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study.
Daniele Antonio PizzutoAntoni Noguera-JulianRossana MoroniAngel Hernández-BartoloméNora FritschiLaura LancellaLaura CursiAleix Soler-GarciaRenate KrügerCornelia Feiterna-SperlingMichela SaliAndrea Lo VecchioSara ScaranoAlicia Hernanz LoboMaria EspiauAntonio Soriano-ArandesBenhur Şirvan ÇetinFolke BrinkmannIveta OzereFernando Baquero-ArtigaoMaria TsoliaTiago Milheiro SilvaMatilde Bustillo-AlonsoAndrea Martín NaldaMargherita ManciniAnna StarshinovaNicole RitzSvetlana VelizarovaLaura Ferreras-AntolínFlorian GötzingerOlga BilogortsevaVira ChechenyevaMarc TebrueggeBegoña Santiago-Garcíanull nullPublished in: Thorax (2022)
The results indicate that the latest generation IGRA assay, QFT-Plus, does not perform better than previous generation IGRAs or the TST in children with TB disease. Overall, tests performed worse in CNS and miliary TB, and in immunocompromised children. None of the tests evaluated had sufficiently high sensitivity to be used as a rule-out test in children with suspected TB.