Cyr61 synthesis is induced by interleukin-6 and promotes migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis.

Changmin ChoiWooseong JeongByeongzu GhangYonggeun ParkChanglim HyunMoonjae ChoJinseok Kim

Published in: Arthritis research & therapy (2020)

By modulating the ERK/EGR3 pathway, IL-6 stimulated Cyr61 production and in turn increased invasiveness of FLS. Our data suggest that Cyr61 might be a potential target to prevent the progression of joint damage in RA.

Keyphrases

rheumatoid arthritis
signaling pathway
disease activity
ankylosing spondylitis
oxidative stress
interstitial lung disease
electronic health record
pi k akt
fluorescent probe
sensitive detection
big data
living cells
systemic sclerosis
deep learning
single molecule
artificial intelligence