The Relationship Between Seizures and Spreading Depolarizations in Patients with Severe Traumatic Brain Injury.
Brandon P ForemanHyunjo LeeDavid O OkonkwoAnthony J StrongClemens PahlLori A ShutterJens P DreierLaura B NgwenyaJed A HartingsPublished in: Neurocritical care (2022)
In patients with severe TBI requiring neurosurgery, seizures were half as common as SDs. Seizures would have gone undetected without ECoG monitoring in 20% of patients. Although seizures alone did not influence 6-month functional outcomes in this cohort, they were independently associated with electrographic worsening and a lack of motor improvement following surgery. Temporal interactions between ECoG-detected seizures and SDs were common and held prognostic implications. Together, seizures and SDs may occur along a dynamic continuum of factors critical to the development of secondary brain injury. ECoG provides information integral to the clinical management of patients with TBI.
Keyphrases