Enhanced protein secretion in reduced genome strains of Streptomyces lividans.

Mohamed Belal HamedTobias BuscheKenneth SimoensSebastien CarpentierJan KormanecLieve Van MellaertJozef AnnéJoern KalinowskiKristel BernaertsSpyridoula KaramanouAnastassios Economou

Published in: Microbial cell factories (2024)

The current study described a strategy to construct chassis strains with enhanced secretory abilities and proposed a model linking the deletion of specialized metabolite biosynthetic clusters to improved production of secreted heterologous proteins.

Keyphrases

escherichia coli
palliative care
genome wide
gene expression
protein protein
amino acid
saccharomyces cerevisiae