Tumor Intrinsic PD-L1 Promotes DNA Repair in Distinct Cancers and Suppresses PARP Inhibitor-Induced Synthetic Lethality.
Anand V R KornepatiJacob T BoydClare E MurrayJulia SaifetiarovaBárbara de la PeñaCody M RogersHaiyan BaiAlvaro S PadronYiji LiaoCarlos OntiverosRobert S SvatekRobert HromasRong LiYanfen HuJosé R Conejo-GarciaRatna K VadlamudiWeixing ZhaoEloïse DrayPatrick SungTyler J CurielPublished in: Cancer research (2022)
PD-L1 upregulates BRCA1-mediated homologous recombination, and PD-L1-deficient tumors exhibit BRCAness by manifesting synthetic lethality in response to PARP inhibitors, revealing an exploitable therapeutic vulnerability and a candidate treatment response biomarker. See related commentary by Hanks, p. 2069.