HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.

Yunzhi LiuQishan XuFan DengZhuojun ZhengJialiang LuoPing WangJia ZhouXiao LuLiyun ZhangZhengliang ChenQifan ZhangQingyun ChenDaming Zuo

Published in: Journal of experimental & clinical cancer research : CR (2023)

Our data identified HERC2 functions as a previously unknown modulator of the JAK2/STAT3 pathway, thereby promoting inflammation-induced stemness and immune evasion in HCC.

Keyphrases

oxidative stress
stem cells
epithelial mesenchymal transition
diabetic rats
papillary thyroid
signaling pathway
high glucose
cell proliferation
electronic health record
squamous cell carcinoma
big data
drug induced
endothelial cells