The Role of Expert Opinion in Projecting Long-Term Survival Outcomes Beyond the Horizon of a Clinical Trial.
Bartholomeus J A WilligersMario OuwensAndrew H BriggsHiddo J L HeerspinkCarol A PollockRoberto Flavio Pecoits-FilhoNavdeep TangriCsaba Pal KovesdyDavid Collins WheelerJuan Jose Garcia SanchezPublished in: Advances in therapy (2023)
Using expert opinion in a Bayesian analysis provided a robust method for extrapolating long-term survival in the placebo arm of DAPA-CKD. The method could be applied to other populations with limited survival data.