Implementing losartan potassium-laden pegylated nanocubic vesicles as a novel nanoplatform to alleviate cisplatin-induced nephrotoxicity via blocking apoptosis and activating the wnt/β-catenin/TCF-4 pathway.

Heba F SalemMohamed M NafadyRasha A KhallafAsmaa Ramadan Abdel-SattarHend Hassan Abdel-SattarEssam M Eissa

Published in: Life sciences (2024)

LP-NCVs-PEG improved LP pharmacokinetics targeting the kidney and improved injury by activating wnt/β-catenin/TCF-4 pathway, blocking apoptosis, inflammation and renal toxicity markers suggesting it might be successful nephroprotective adjuvant therapy.

Keyphrases

oxidative stress
cell proliferation
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
epithelial mesenchymal transition
cancer therapy
stem cells
cell death
pi k akt
drug delivery
photodynamic therapy
angiotensin ii
quality improvement
drug release