Nobiletin derivative, 5-acetoxy-6,7,8,3',4'-pentamethoxyflavone, inhibits neuroinflammation through the inhibition of TLR4/MyD88/MAPK signaling pathways and STAT3 in microglia.
Jimmy Ming-Jung ChuangHsien-Lin ChenChi-I ChangJia-Syuan LinHui-Min ChangWan-Ju WuMei-Ying LinWu-Fu ChenChien-Hsing LeePublished in: Immunopharmacology and immunotoxicology (2024)
Our findings suggest that 5-Ac-Nob represses neuroinflammatory responses by inhibiting TLR4-mediated signaling pathway and STAT3. As a result of these findings, 5-Ac-Nob has potential as an anti-inflammatory agent against microglia-mediated neuroinflammatory disorders.
Keyphrases
- signaling pathway
- inflammatory response
- toll like receptor
- pi k akt
- lipopolysaccharide induced
- lps induced
- induced apoptosis
- anti inflammatory
- epithelial mesenchymal transition
- cell proliferation
- immune response
- neuropathic pain
- traumatic brain injury
- nuclear factor
- spinal cord
- oxidative stress
- climate change
- human health
- brain injury