PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer.
Hannah S NewtonVaibhavkumar S GawaliAmeet A ChimoteMaria A LehnSarah M PalackdharryBenjamin H HinrichsRoman JandarovDavid HildemanEdith M JanssenTrisha M Wise-DraperLaura ConfortiPublished in: Journal for immunotherapy of cancer (2021)
Pembrolizumab enhanced K+ channel activity, Ca2+ fluxes and chemotaxis of CD8+ T cells in patients with HNSCC, with a unique pattern of response in responder patients that is conducive to the heightened functionality of their cytotoxic T cells.