Wnt5a-induced docking of Plk1 on HEF1 promotes HEF1 translocation and tumorigenesis.

Jeong-Ah HwangJi Eun YuSun-Ok KimDong Hyun KimKyoung Sang ChoKyung Ho Lee

Published in: Genes & genomics (2021)

Our data collectively unveil the Wnt5a-CK1δ-HEF1-Plk1-FA remodeling pathway that governs HEF1 transportation to the FA to induce cell migration and tumorigenesis. This study sheds light on a mechanism underlying tumorigenesis and provides new strategies for anticancer therapy.

Keyphrases

cell migration
cell proliferation
stem cells
molecular dynamics
high glucose
electronic health record
molecular dynamics simulations
diabetic rats
machine learning
mesenchymal stem cells
protein protein
endothelial cells