A Universal Multichannel Platform for Assembling Enzyme-Based Boolean Logic Gates.

Yacob MelmanEvgeny KatzOleh Smutok

Published in: Chemphyschem : a European journal of chemical physics and physical chemistry (2022)

Concatenated enzyme-based Boolean logic gates activated with 5 chemical input signals were analyzed with a smartphone photo camera. Simultaneous detection of 32 input combinations was conveniently performed using enzyme-modified fiberglass sensing spots generating fluorescence with different intensities for the 0 and 1 binary outputs. The developed technology offers an easy readout method for multi-channel logic systems.

Keyphrases

high throughput
single molecule
loop mediated isothermal amplification
high speed
mass spectrometry
energy transfer
deep learning