Monitorable Mitochondria-Targeting DNAtrain for Image-Guided Synergistic Cancer Therapy.
Tao JiangLihua ZhouHaixiang LiuPengfei ZhangGuozhen LiuPing GongChunbin LiWeihong TanJianhai ChenLintao CaiPublished in: Analytical chemistry (2019)
It is highly desirable to realize real-time monitoring of the drug delivery/release process in cancer treatment. Herein, a monitorable mitochondria-specific DNAtrain (MitoDNAtrs) was developed for image-guided drug delivery and synergistic cancer therapy. In this system, mitochondria-targeting Cy5.5 dye served as the "locomotive" to guide the DNA "vehicle" selectively accumulating in the cancer cells in a detectable manner. More importantly, Cy5.5 showed reactive oxygen species (ROS) generation ability, which made it a promising adjuvant chemotherapy amplifier for cancer theranostics.