The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling.

Kinga SałaciakMonika Głuch-LutwinAgata SiwekMałgorzata SzafarzGrzegorz KazekMarek BednarskiLeszek NowińskiEmma MitchellMagdalena Jastrzębska-WięsekAnna PartykaAnna WesołowskaMarcin KołaczkowskiNatalia SzkaradekHenryk MaronaJacek SapaKarolina Pytka

Published in: Journal of psychopharmacology (Oxford, England) (2020)

Xanthone derivatives with N-(2-methoxyphenyl)piperazine fragment and hydroxypropoxy linker show increased binding to the 5-HT1A receptor and may represent an attractive putative treatment candidate for depression.

Keyphrases

depressive symptoms
major depressive disorder
binding protein
physical activity
mass spectrometry
bipolar disorder