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Host Amplification in a Dithioacetal-Based Dynamic Covalent Library.

A Gastón OrrilloAndrea M EscalanteRicardo Luis Eugenio Furlan
Published in: Organic letters (2017)
Molecular amplification in a dithioacetal-based dynamic library is described for the first time. The homatropine induced selection, amplification, and isolation of one cyclophane host demonstrates the utility of dithioacetal exchange for preparing responsive dynamic libraries. Nuclear magnetic resonance and isothermal titration calorimetry analysis suggest that the amplified macrocycle forms a 1:1 complex with the template. This is the first report about a host/guest system involving a dithioacetal cyclophane.
Keyphrases
  • nucleic acid
  • magnetic resonance
  • label free
  • magnetic resonance imaging
  • single molecule
  • mass spectrometry