Natural History of Germline BRCA1 Mutated and BRCA Wild-type Triple-negative Breast Cancer.

Nilesh Laxman Gardi Rohan Chaubal Pallavi Parab Sunil Pachakar Suyash Sureshchandra Kulkarni Tanuja Shet Shalaka Joshi Yogesh Kembhavi Pratik Chandrani Jelmar Quist Pradnya Kowtal Anita Grigoriadis Rajiv Sarin Raman Govindarajan Sudeep Gupta

Published in: Cancer research communications (2024)

In germline BRCA1 mutated and BRCA wild-type patients, TNBC shows a branching evolutionary pattern of mutations with a single founding clone, are polyclonal throughout their disease course, and have widespread copy-number aberrations. This evolutionary pattern may be associated with treatment resistance or sensitivity and could be therapeutically exploited.

Keyphrases

wild type
copy number
genome wide
mitochondrial dna
breast cancer risk
end stage renal disease
newly diagnosed
ejection fraction
dna methylation
dna repair
peritoneal dialysis
prognostic factors
gene expression
patient reported outcomes
dna damage