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Neutral rhodol-based dyes expressing localization in mitochondria.

Ilaria FerraboschiJuraj OvčarKateryna V VygranenkoShupei YuAlfonso MinervinoAntoni WrzosekAdam SzewczykRiccardo RozzaAlessandra MagistratoKevin D BelfieldDaniel T GrykoLuca GrisantiCristina Sissa
Published in: Organic & biomolecular chemistry (2024)
Neutral rhodol-based red emitters are shown to efficiently localize in mitochondria, as demonstrated by confocal microscopy and co-localization studies. A simple model is proposed to explain the localization mechanism of neutral molecules. The model takes into account the strong coupling between the molecular dipole moment and the electric field of the inner mitochondrial membrane.
Keyphrases
  • cell death
  • oxidative stress
  • reactive oxygen species
  • endoplasmic reticulum