Body mass index change and estimated glomerular filtration rate decline in a middle-aged population: health check-based cohort in Japan.
Shingo FukumaTatsuyoshi IkenoueJennifer L Bragg-GreshamEdward NortonYukari YamadaDaichi KohmotoRajiv SaranPublished in: BMJ open (2020)
In the middle-aged Japanese population, both, increase and decrease in BMI were associated with subsequent eGFR decline. Changes in risk factors mediated a small proportion of the association between BMI increase and eGFR decline. Our findings support the clinical significance of monitoring BMI as a renal risk factor.