Modulation of Inflamed Synovium Improves Migration of Mesenchymal Stromal Cells in Vitro Through Anti-Inflammatory Macrophages.
Marinus Anthonie WesdorpYvonne M Bastiaansen-JenniskensSerdar CaparJan A N VerhaarR NarcisiGerjo J V M Van OschPublished in: Cartilage (2022)
Macrophages secrete factors that stimulate the migration of MSCs. Modulation with TAA increased specifically the ability of anti-inflammatory macrophages to stimulate migration, indicating that they play an important role in secreting factors to attract MSCs. Modulating inflammation and thereby improving migration could be used in approaches based on endogenous repair of full-thickness cartilage defects.