Risk of Colorectal Carcinoma May Predispose to the Genetic Variants of the GST, CYP450, and TP53 Genes Among Nonsmokers in the Saudi Community.

Ikhlas A SindiAhmed O BabalghithMohammed T TayebAhmad H MuftiHind NaffadiSamar N EkramEzzeldin N ElhawaryMunaifah AleneziNasser Attia Elhawary

Published in: International journal of general medicine (2021)

The GSTM1 and TP53 rs1042522 variants can increase the development of CRC in Saudi nonsmokers. Even the presence of one copy of a variant allele in the CYP1A1 gene can predispose CRC risk. Additional studies should also examine other SNP combinations with lifestyle factors that may help prevent, rather than facilitate, colorectal tumorigenesis.

Keyphrases

genome wide
copy number
genome wide identification
dna methylation
saudi arabia
mental health
metabolic syndrome
healthcare
physical activity
weight loss
cardiovascular disease
genome wide analysis
transcription factor
high density
case control
genetic diversity