Homeostatic iron regulatory protein drives glioblastoma growth via tumor cell-intrinsic and sex-specific responses.
Katie M TroikeSabrina Z WangDaniel J SilverJuyeun LeeErin E Mulkearns-HubertNicole HajdariPrabar K GhoshKristen E KayJulia L BeilisSofia E MitchellChristopher W BishopEllen S HongMykyta ArtomovChristopher G HubertPrajwal RajappaJames R ConnorPaul L FoxBjarne Winther KristensenJustin D LathiaPublished in: Neuro-oncology advances (2023)
These findings reveal an essential function for HFE in GBM cell growth and survival, as well as a sex-specific interaction with the immune response.