Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease.

Vasiliki LygirouAgnieszka LatosinskaManousos MakridakisWilliam MullenChristian DellesJoost P SchanstraJerome ZoidakisBurkert PieskeHarald MischakAntonia Vlahou

Published in: Journal of translational medicine (2018)

This proteomic study provides a comprehensive dataset to be used for integrative and functional studies in the field. The observed protein changes reflect known CVD-related processes (e.g. lipid uptake, inflammation) but also novel hypotheses for further investigation including a potential pleiotropic role of LPR2 but also links of SZT2 to CVD.

Keyphrases

cardiovascular disease
protein protein
oxidative stress
binding protein
type diabetes
small molecule
risk assessment
cardiovascular events
metabolic syndrome
network analysis
drug induced