Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.

Po-Chih ShenShih-Hsiang ChouCheng-Chang LuHsuan-Ti HuangSong-Hsiung ChienPeng-Ju HuangZi-Miao LiuChia-Lung ShihShu-Jem SuLi-Min ChenYin-Chun Tien

Published in: Cartilage (2021)

Shockwaves activated Nrf2 activity through the induction of transient ROS signaling and subsequently enhanced ECM synthesis in chondrocytes. This study provided fundamental evidence confirming the potential of shockwaves for OA management.

Keyphrases

extracellular matrix
signaling pathway
oxidative stress
dna damage
cell death
pi k akt
reactive oxygen species
epithelial mesenchymal transition
induced apoptosis
knee osteoarthritis
risk assessment
human health
combination therapy