Joint Hypermobility, Autonomic Dysfunction, Gastrointestinal Dysfunction, and Autoimmune Markers: Clinical Associations and Response to Intravenous Immunoglobulin Therapy.
Pankaj J PasrichaMegan McKnightLuisa VillatoroGuillermo BarahonaJeffrey BrinkerKen HuiMichael PolydefkisRobert BurnsZsuzsanna H McMahanNeda F GouldBrent GoodmanJoseph HentzGlenn TreismanPublished in: The American journal of gastroenterology (2024)
Autoimmune markers and autonomic dysfunction are common in patients with unexplained GI symptoms, especially in those with JH/HSD. Many patients seem to respond to IVIG treatment, but this needs to be confirmed by controlled trials. These results highlight the need for vigilance for autoimmune and autonomic factors and JH/HSD in patients with neurogastroenterological disorders. Clinicaltrials.gov , NCT04859829.
Keyphrases
- heart rate variability
- multiple sclerosis
- heart rate
- end stage renal disease
- oxidative stress
- ejection fraction
- newly diagnosed
- chronic kidney disease
- drug induced
- peritoneal dialysis
- high dose
- prognostic factors
- stem cells
- depressive symptoms
- bone marrow
- mesenchymal stem cells
- replacement therapy
- cell therapy
- smoking cessation