COVID-19: molecular targets, drug repurposing and new avenues for drug discovery.
Mario Roberto SengerTereza Cristina Santos EvangelistaRafael Ferreira DantasMarcos Vinicius da Silva SantanaLuiz Carlos Saramago GonçalvesLauro Ribeiro de Souza NetoSabrina Baptista FerreiraFloriano Paes Silva-JrPublished in: Memorias do Instituto Oswaldo Cruz (2020)
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment.