Clinical and Immunological Features of SARS-CoV-2 Breakthrough Infections in Vaccinated Individuals Requiring Hospitalization.
Giulia LamacchiaAlessio MazzoniMichele SpinicciAnna VanniLorenzo SalvatiBenedetta PeruzziSara BenciniManuela CaponeAlberto CarnascialiParham FarahvachiArianna RoccaSeble Tekle KirosLucia GrazianiLorenzo ZammarchiJessica MencariniMaria Grazia ColaoRoberto CaporaleFrancesco LiottaLorenzo CosmiGian Maria RossoliniAlessandro BartoloniLaura MaggiFrancesco AnnunziatoPublished in: Journal of clinical immunology (2022)
Despite more severe pre-existing clinical conditions, vaccinated patients have good outcome. A rapid activation of anti-SARS-CoV-2-specific immunity is fundamental for the resolution of the infection. Therefore, prior immunization through vaccination provides a significant contribution to prevention of disease worsening and can even overcome the presence of high-risk factors (i.e., older age, comorbidities, anti-IFN-α autoantibodies).