Peripheral Serum Exosomes Isolated from Patients with Acute Myocardial Infarction Promote Endothelial Cell Angiogenesis via the miR-126-3p/TSC1/mTORC1/HIF-1α Pathway.
ShaSha DuanChao WangXiangli XuXiaoshan ZhangGaofeng SuYou LiShuai FuPing SunJia-Wei TianPublished in: International journal of nanomedicine (2022)
Collectively, our results provide a novel understanding of the function of exosomes in angiogenesis post AMI. We demonstrated that exosomes from the peripheral serum of AMI patients promote angiogenesis via the miR-126-3p/TSC1/mTORC1/HIF-1α signaling pathway.
Keyphrases
- endothelial cells
- acute myocardial infarction
- mesenchymal stem cells
- vascular endothelial growth factor
- stem cells
- signaling pathway
- end stage renal disease
- high glucose
- percutaneous coronary intervention
- ejection fraction
- left ventricular
- chronic kidney disease
- pi k akt
- heart failure
- cell proliferation
- coronary artery disease
- atrial fibrillation
- oxidative stress
- epithelial mesenchymal transition
- patient reported