Longitudinal cognitive assessment in patients with primary CNS lymphoma treated with induction chemotherapy followed by reduced-dose whole-brain radiotherapy or autologous stem cell transplantation.
Denise D CorreaErica BraunMaria Kryza-LacombeKa-Wai HoAnne S ReinerKatherine S PanageasJoachim YahalomCraig S SauterLauren E AbreyLisa M DeAngelisAntonio OmuroPublished in: Journal of neuro-oncology (2019)
Results indicated improvement in cognitive function up to 3 years post-treatment, but a decline at later time points and an increase in brain structure abnormalities in both groups. The findings suggest that rdWBRT and HDC-ASCT may be associated with delayed neurotoxicity in progression-free patients and underscore the need for long-term follow-up to characterize cognitive dysfunction in PCNSL patients.
Keyphrases
- end stage renal disease
- stem cell transplantation
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- white matter
- squamous cell carcinoma
- locally advanced
- resting state
- mesenchymal stem cells
- radiation therapy
- functional connectivity
- multiple sclerosis
- cell therapy
- brain injury
- radiation induced