Lymphotoxin beta-activated LTBR/NIK/RELB axis drives proliferation in cholangiocarcinoma.

Kaiyu XuAnnika KesslerFederico NichettiPaula Hoffmeister-WittmannAnna-Lena ScherrLuisa NaderEblina KelmendiNathalie SchmittMaximilian SchwabMaría García-BeccariaBenjamin SobolOsama Azzam NietoHanna IseleUlrike GärtnerNuria Vaquero-SigueroJulia VolkFelix KorellAndreas MockDanijela HeidePierluigi RamadoriBénédicte LenoirThomas AlbrechtJennifer HülleinDirk JägerStefan FröhlingChristoph SpringfeldRene JackstadtMathias HeikenwälderMichael T DillStephanie RoesslerBenjamin GoeppertBruno Christian Köhler

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

Our study confirms that the non-canonical NF-κB axis LTβ/NIK/RelB drives cholangiocarcinogenesis and represents a candidate therapeutic target.

Keyphrases

signaling pathway
oxidative stress
lps induced
immune response
inflammatory response
cell proliferation