Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma.

Steven I ParkCarolina P LinNatalie RenSteven P AngusDirk P DittmerMichael FooteTrevor PartonAadra P BhattYuri D FedoriwDaniel P RothMarissa L CannGary L JohnsonBlossom Damania

Published in: Targeted oncology (2020)

Our data demonstrate that AURKA inhibition induces synthetic lethality and overcomes chemoresistance in Myc-overexpressing lymphoma. The combination of MLN8237 and conventional chemotherapy showed promising safety and anti-tumor activities in preclinical models of Myc-positive NHL.

Keyphrases

transcription factor
diffuse large b cell lymphoma
locally advanced
big data
stem cells
cell therapy
chemotherapy induced
machine learning
rectal cancer
deep learning