Glutamine mitigates oxidative stress-induced matrix degradation, ferroptosis, and pyroptosis in nucleus pulposus cells via deubiquitinating and stabilizing Nrf2.

Jiajun WuWeitao HanYangyang ZhangShuangxing LiTianyu QinZhengqi HuangChao ZhangMing ShiYuliang WuWanli ZhengBo GaoKang XuWei Ye

Published in: Antioxidants & redox signaling (2024)

A direct correlation is evident in the progression of IDD between the processes of pyroptosis and ferroptosis. Glutamine suppressed oxidative stress-induced cellular processes, including pyroptosis, ferroptosis, and ECM degradation through deubiquitinating Nrf2 and inhibiting lipid oxidation in NP cells. Glutamine is a promising novel therapeutic target for the management of IDD.

Keyphrases

cell death
induced apoptosis
cell cycle arrest
oxidative stress
nlrp inflammasome
signaling pathway
endoplasmic reticulum stress
cell proliferation
radiation therapy