Are Anti-rhGAA Antibodies a Determinant of Treatment Outcome in Adults with Late-Onset Pompe Disease? A Systematic Review.

Imke A M DittersHarmke A van KootenNadine A M E van der BeekAns T van der PloegHidde H Huidekoper Johanna M P van den Hout

Published in: Biomolecules (2023)

No clear effect of anti-rhGAA IgG antibodies on treatment response could be established for the majority of LOPD patients with a high antibody titre. In a minority of patients, a clinical decline related to (possible) interference of anti-rhGAA antibodies was described.

Keyphrases

late onset
early onset
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
replacement therapy
drug induced