Tibolone, alendronate, and simvastatin enhance implant osseointegration in a preclinical in vivo model.

Dragos Apostu Ondine Patricia Lucaciu Alexandru Mester Daniel Oltean-Dan Dan Gheban Horea Rares Ciprian Benea

Published in: Clinical oral implants research (2020)

The hypothesis that alendronate, simvastatin, and tibolone enhance the osseointegration process of intramedullary titanium implants in ovariectomized rats has been accepted, while tibolone could offer the best results.

Keyphrases

soft tissue
cell therapy
bone loss
mesenchymal stem cells
bone marrow