Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot.

Aaron J StoreyHsin-Ping WangReine U ProtacioMari K DavidsonAlan J TackettWayne P Wahls

Published in: Epigenetics & chromatin (2018)

Overall, our findings indicate that a remarkably diverse collection of chromatin remodeling factors and histone PTMs participate in designating where meiotic recombination occurs in the genome, and they provide new insight into molecular mechanisms of the process.

Keyphrases

dna damage
dna repair
transcription factor
genome wide
gene expression
oxidative stress
dna methylation
mass spectrometry
label free