Angiopoietin-like 4 is upregulated by amphiregulin and activates cell proliferation and migration through p38 kinase in head and neck squamous cell carcinoma.
Ajay KumarEmmanuel AsieduEman HefniCheryl ArmstrongDeepak MenonTao MaLauren SandsEberechi MbadughaAkrit SodhiAbraham SchneiderSilvia MontanerPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2024)
Our results demonstrate that angiopoietin-like 4 is a downstream effector of amphiregulin and promotes head and neck squamous cell carcinoma development both through direct activation of p38 kinase as well as paracrine mechanisms.