TBX15/miR-152/KIF2C pathway regulates breast cancer doxorubicin resistance via promoting PKM2 ubiquitination.

Cheng-Fei JiangYun-Xia XieYing-Chen QianMin WangLing-Zhi LiuYong-Qian ShuXiao-Ming BaiBing-Hua Jiang

Published in: Cancer cell international (2021)

Our data identify a new mechanism by which TBX15 abolishes DOX chemoresistance in breast cancer, and suggest that TBX15/miR-152/KIF2C axis is a novel signaling pathway for mediating DOX resistance in breast cancer through regulating PKM2 ubiquitination and decreasing PKM2 stability. This finding suggests new therapeutic target and/or novel strategy development for cancer treatment to overcome drug resistance in the future.

Keyphrases

cell proliferation
long non coding rna
signaling pathway
long noncoding rna
drug delivery
pi k akt
machine learning
breast cancer risk
young adults
big data
induced apoptosis