LncRNA SPRY4-IT1 facilitates cell proliferation and angiogenesis of glioma via the miR-101-3p/EZH2/VEGFA signaling axis.

Ji Wang Yanming ChenQing WangHui XuQianqian JiangMan WangShenggang LiYing ChenChunwang WuPei YuZongyu XiaoWenjin ChenQing Lan

Published in: Cancer medicine (2022)

Our findings provide compelling evidence showing that SPRY4-IT1 upregulated EZH2 to induce VEGFA by sponging miR-101-3p, thereby achieving cell proliferation and angiogenesis in glioma. Therefore, targeting SPRY4-IT1/miR-101-3p/EZH2/VEGFA axis may improve the outcomes of patients with glioma.

Keyphrases

cell proliferation
long noncoding rna
long non coding rna
endothelial cells
cell cycle
vascular endothelial growth factor
wound healing
pi k akt
skeletal muscle
adipose tissue
weight loss