Impact of brain atrophy on tDCS and HD-tDCS current flow: a modeling study in three variants of primary progressive aphasia.
Gozde UnalBronte FicekKimberly WebsterSyed ShahabuddinDennis TruongBenjamin HampsteadMarom BiksonKyrana TsapkiniPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2020)
Limited to the conditions and assumptions considered here, this argues against a specific need to adjust the tDCS montage for these patients any more than might be considered useful in anatomically typical adults. Therefore, local atrophy does not, in isolation, reliably predict local electric field. Rather, our results are consistent with holistic head anatomy influencing brain current flow, with tDCS producing diffuse and individualized brain current flow patterns and HD-tDCS producing targeted brain current flow across individuals.
Keyphrases
- transcranial direct current stimulation
- resting state
- white matter
- functional connectivity
- end stage renal disease
- cerebral ischemia
- multiple sclerosis
- working memory
- ejection fraction
- newly diagnosed
- gene expression
- chronic kidney disease
- copy number
- dna methylation
- drug delivery
- blood brain barrier
- cancer therapy
- high grade