Liver Transplantation in People Living with HIV: Still an Experimental Procedure or Standard of Care?
Erica Nicola LynchFrancesco Paolo RussoPublished in: Life (Basel, Switzerland) (2023)
Liver transplantation (LT) is the only curative treatment for various liver diseases, including acute liver failure, end-stage liver disease, and selected unresectable liver malignancies. Combination antiretroviral therapy has improved outcomes for people living with HIV (PLWH), transforming the status of acquired immune deficiency syndrome from a fatal disease to a chronic and manageable condition. These powerful antiviral therapies have not only increased the number of HIV+ enlisted patients by improving their survival but also made the use of HIV+ organs a viable option. In this review, we summarise current knowledge on the peculiarities of liver transplantation in PLWH. In particular, we focus on the indications, contraindications, specific considerations for treatment, and outcomes of LT in PLWH. Finally, we present available preliminary data on the use of HIV+ liver allografts.
Keyphrases
- antiretroviral therapy
- liver failure
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv aids
- hiv infected patients
- hiv testing
- hepatitis c virus
- healthcare
- men who have sex with men
- hepatitis b virus
- prognostic factors
- palliative care
- south africa
- newly diagnosed
- ejection fraction
- patient reported outcomes
- intensive care unit
- squamous cell carcinoma
- metabolic syndrome
- acute respiratory distress syndrome
- radiation therapy
- electronic health record
- extracorporeal membrane oxygenation
- free survival
- machine learning
- data analysis
- respiratory failure