Blockade of JAK2 protects mice against hypoxia-induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation.

Lei ZhangYi WangGuorao WuLizong RaoYanqiu WeiHuihui YueTing YuanPing YangFei XiongShu ZhangQing ZhouZhishui ChenJinxiu LiBi-Wen MoHuilan ZhangWeining XiongCong-Yi Wang

Published in: Cell proliferation (2020)

Our studies support that JAK2 could be a culprit contributing to the pulmonary vascular remodelling, and therefore, it could be a viable target for prevention and treatment of PAH in clinical settings.

Keyphrases

pulmonary arterial hypertension
pulmonary hypertension
smooth muscle
pulmonary artery
cell proliferation
metabolic syndrome
pi k akt
type diabetes