Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.

Bo-Feng YinZhi-Ling LiZi-Qiao YanZheng GuoJia-Wu LiangQian WangZhi-Dong ZhaoPei-Lin LiRui-Cong HaoMeng-Yue HanXiao-Tong LiNing MaoLi DingDa-Fu ChenYue GaoHeng Zhu

Published in: Stem cell research & therapy (2022)

In summary, our findings identified psoralen as a potential medicine to mitigate bone radiation injury. In addition, skeletal stem cells and AKT-GSK-3β and NRF2 may thus represent therapeutic targets for treating radiation-induced bone injury.

Keyphrases

radiation induced
stem cells
signaling pathway
radiation therapy
bone mineral density
cell proliferation
oxidative stress
pi k akt
soft tissue
bone loss
bone regeneration
cell therapy
body composition
risk assessment
bone marrow
long non coding rna
human health