Native mass spectrometry interrogation of complexes formed during targeted protein degradation.

Ikhlas Mohamed Mohamud Ahmed Rebecca Beveridge

Published in: Rapid communications in mass spectrometry : RCM (2023)

Here, we provide step-by-step instructions for the sample preparation of PROTAC complexes and their nMS interrogation to obtain optimal information on their binding modes.

Keyphrases

mass spectrometry
binding protein
liquid chromatography
high resolution
cancer therapy
capillary electrophoresis
gas chromatography
healthcare
high performance liquid chromatography
health information
molecularly imprinted
amino acid
dna binding
ms ms