Nitric oxide-releasing micelles with intelligent targeting for enhanced anti-tumor effect of cisplatin in hypoxia.

Yan ChenLei FangWeixin ZhouJinghan ChangXiaojuan ZhangChuanchuan HeChen ChenRuicong YanYakai YanYao LuChuanrui XuGuangya Xiang

Published in: Journal of nanobiotechnology (2021)

The designed micelles significantly enhanced anti-tumor effects both in vitro and in vivo. These results suggested that CTP/CDDP represented a promising strategy to treat resistance and metastatic tumors.

Keyphrases

cancer therapy
nitric oxide
drug delivery
drug release
squamous cell carcinoma
small cell lung cancer
hyaluronic acid
hydrogen peroxide