Quantitative assessment of dosimetric effect of using alternative OAR delineations in treatment planning as functions of delineations, setup uncertainty and planning techniques using an alternative truth assessment method.

The findings highlight the necessity for comprehensive Quality Assurance programs in radiotherapy, incorporating both dosimetric impact analysis and geometric variation assessment to ensure optimal delineation quality. The study emphasizes the complex dynamics of treatment planning in radiotherapy, advocating for personalized, case-specific strategies in clinical practice to enhance patient care quality and efficacy in the face of varying SV and delineation accuracies.